Why do I need this test?
Esophageal cancer (Esophageal Adenocarcinoma) is the seventh leading cause of cancer-related death and the eleventh most common cancer6.
Esophageal cancer consists of two main subtypes: esophageal squamous cell carcinoma and esophageal adenocarcinoma. In Western countries, EAC is the predominant type of esophageal cancer.
Current screening methods (endoscopy with biopsy) are invasive and yet many cases are not identified until late stage cancer is present, while misdiagnosis can lead to over or under-treatment8,9.
This new Esophageal Health Test is a non-invasive, cost-effective blood test designed to rule out esophageal adenocarcinoma with a high level of accuracy.
Esophageal Health Test vs Endoscopy
Esophageal Health Test vs Endoscopy:
- Simple, non-invasive blood test vs invasive procedure
- Quick test vs potentially a long waiting period for the endoscopy to be scheduled and having to take time off work
- Results within 2 to 4 weeks vs potentially a long waiting time for the endoscopy to be scheduled as well as 1-3 weeks for the results
Endoscopy also requires:
- fasting the night prior to procedure
- someone to drive the patient home from the hospital/clinic after the procedures.
Cost benefits
Private health insurance patients also face significant co-payment for their endoscopy procedure, as well as their GI specialist office visit(s).
Who should take this test?
People with chronic acid reflux (also known as Gastro-esophageal Reflux Disease - GERD) who are discussing endoscopy with their doctor to rule out a common type of esophageal cancer called esophageal adenocarcinoma.
Suitable candidates include people who have been diagnosed with Barrett’s oesophagus who are on surveillance endoscopy.
Eligibility criteria for this test include:
- no prior cancer diagnosis
- frequent heartburn or chronic acid reflux (GERD)
- at least one risk factors for esophageal adenocarcinoma, including:
- Age > 50 years
- Overweight (BMI > 25 kg/m2)
How does the test work?
The test measures four glycoprotein biomarkers in the blood, and these measurements are then combined with age, sex and BMI in a statistical model to assess your risk of esophageal adenocarcinoma.
The test results use a traffic light system to classify your risk of esophageal adenocarcinoma:
- Green = low risk of esophageal adenocarcinomao
- Amber = moderate risk of esophageal adenocarcinoma
- Red = high risk of esophageal adenocarcinoma
What happens after I get my result?
A green result will give you peace of mind. If your result is amber or high risk, your doctor will likely recommend further evaluation to confirm the diagnosis and guide treatment. This may include:
- Referral to a Specialist: You may be referred to a gastroenterologist for further assessment.
- Diagnostic Tests: Additional tests, such as an endoscopy and biopsy, may be conducted to confirm the presence of esophageal cancer or pre-cancerous changes.
- Monitoring and Treatment Planning: Based on your results, your doctor may create a tailored plan, which could involve regular monitoring, lifestyle changes, or early treatment options to manage or reduce your risk.
Available from 17th Sept, 2025
Esophageal Health Test
Gastro-esophageal reflux disease (GERD) affects 1 in 10 Australians but it could be more serious than you think.1
GERD is one of the most common gastrointestinal conditions in Australia.1 While often manageable, long-term acid reflux can damage your esophageal lining and increase your risk of developing a type of esophageal cancer called esophagael adenocarcinoma.2,3,4
Most people with GERD will never develop esophageal adenocarcinoma.5 However, based on your individual circumstances and risk factors, your doctor may choose to investigate further, usually with an endoscopy.
Now, there’s a simpler way to assess your cancer risk.
This new blood test can help estimate your risk of esophageal adenocarcinoma quickly and conveniently.
Compared with endoscopy. this test is:
- Faster – just a standard blood draw
- Easier – no fasting, sedation or recovery time
- More convenient – no time off work or someone to drive you home after the procedure.
Your blood sample is analysed in our lab and we provide the test report within 2 to 4 weeks. To find out more, talk to a doctor about this test. Or take our free eligibility check.
For patients with persistent heartburn or GERD
Rule out esophageal adenocarcinoma (cancer)
Sample Type: Blood Test
Authorisation: Telehealth consult included
Results: 2 to 4 weeks from sample collection
How it works
1
Check if you are eligible
Answer a few quick questions about your health online. If you're eligible you can purchase a consultation.
2
Talk to a doctor over the phone
Book a telehealth consultation with a licensed doctor to approve your test request.
3
Provide your sample
Take your request form to a participating collection centre to have your blood samples taken.
4
Get answers in days
Once your results are ready, you’ll receive communication whether an online follow-up with your doctor (included in test cost) to review your results is necessary.
This test is not currently accredited by NATA. It is performed in our laboratory, which is accredited for compliance with NPAAC Standards and ISO 15189. All results are generated under the same quality management system applied to our accredited testing.
Risk-free Guarantee
If your doctor feels the Esophageal Health Test isn’t right for you during your initial consultation, you’ll receive a full refund for the test, no questions asked.
Your results
Highly accurate
The Esophageal Health Test has been shown to rule out Esophageal cancer with 99.9% accuracy (Negative Predictive Value)11.
Simple and convenient
This test requires a standard blood collection, analysed by our lab,
which will provide a report on your risk for esophageal adenocarcinoma.
Fast, high-quality results
Your sample is analysed in our accredited Australian lab.
Make informed health choices
These results may help you and your doctor better manage your
chronic acid reflux and better understand your risk of esophageal
adenocarcinoma.
You have questions, we have answers
Easy to access, and even easier to understand.
How does the test help rule out esophageal adenocarcinoma?
The Esophageal Health Test is a non-invasive blood test for the detection of Esophageal cancer. It identifies 4 biomarkers in the blood that are linked with this type of cancer, then combines this with age and body mass index (BMI) data to calculate a risk score. Clinical studies validating this test have reported high accuracy, with the test's ability to "rule out" Esophageal Cancer with a 99.9% negative predictive value11.
Am I eligible for the test?
To be eligible, you must not have had prior cancer diagnosis and exhibit frequent heartburn or acid reflux (also known as Gastro-esophageal Reflux Disease (GERD)).
You also need to have at least one of two risk factors for EAC, including:
• Age > 50 years
• Overweight BMI > 25 kg/m2
How do I do the test?
Follow these simple steps to take the Esophageal Health Test.
1. Purchase the test online here.
2. Book a telehealth consult. If the test is suitable for you, you will receive a pathology referral.
3. Take the referral to a collection centre and have your blood sample taken.
4. Wait for the referring doctor to contact you with results.
How much does it cost and can I get a Medicare rebate?
The telehealth consultation costs $50, the Esophageal Health Test costs $940 and are currently not covered by Medicare.
Can I get a refund if it turns out I’m not eligible?
Yes, we will give you a full refund if you purchase the test but are not eligible to go ahead with it.
How long until I get my results?
2 to 4 weeks depending on where you are located.
Are my results and personal details kept private?
We know health information is sensitive and take your privacy very seriously. Your test results are private and confidential – only you and your referring doctor have access to them.
We store your personal information on highly secure, encrypted servers and will never share your information with third parties without your permission. See our Privacy Policy for further information.
Do I need a doctor's referral?
You don’t need a referral from your usual GP to do the Esophageal Health Test. One of our telehealth partner doctors can approve the pathology request for you. The cost of this consult is included in the purchase price.
References
- Keung C, Hebbard G. The management of gastro-oesophageal reflux disease. Aust Prescr. 2016;39(1):6-10.
- van Zanten SV. Chronic GERD and risk of esophageal adenocarcinoma: Should we screen with gastroscopy? CMAJ. 2020;192(27):E781-E782.
- Tran CL, et al. Gastroesophageal reflux disease and risk of cancer: Findings from the Korean National Health Screening Cohort. Cancer Med. 2023;12(18):19163-19173.
- McColl KE. What is causing the rising incidence of esophageal adenocarcinoma in the West and will it also happen in the East? J Gastroenterol 2019;54(8):669-673.
- Rubenstein JH, Shaheen NJ. Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma. Gastroenterology 2015;149:302-317.
- Bray F. et al, (2024) CA Cancer J Clin. 74(3), 229-263
- Dam et al., (2020) Ann. Transl. Med., 8(17): 1107
- Stawinski et al., (2023) Diagnostics (Basel). 13(2), 321.
- Visrodia et al., (2016) Gastro., 150(3), 599-607.e7
- https://www.proteomics.com.au/wp-content/uploads/240201-ASX-PIQ-Study-validates-biomarkers-for-oesophageal-cancer-blood-test.pdf
- Sheahan J, et al., A Clinical Validation of a Diagnostic Test for Esophageal Adenocarci noma Based on a Novel Serum Glycoprotein Biomarker Panel: PromarkerEso. Proteomes (2025). 13(2), 23.
Take your next step with confidence
Know your risk and your doctor can help you make your next healthcare decision with confidence.